What is HCG / gonadorelin and how does it work?
HCG (human chorionic gonadotropin) mimics luteinizing hormone (LH) and signals the testes directly to stay active. Gonadorelin is a GnRH analog that prompts the pituitary to release LH and FSH, working one step higher up the same hormone axis. Both are subcutaneous injectables used to keep the testes producing — which is why they're used to preserve fertility and testicular function.
Why is it added to TRT?
Testosterone therapy adds testosterone from outside the body, which can signal the testes to slow down — often reducing sperm production and testicular size over time. Adding HCG or gonadorelin keeps the testes stimulated while you stay on testosterone, which is why it's a common companion to TRT. Your provider decides whether it fits your labs and goals.
Will it help preserve my fertility?
HCG and gonadorelin are frequently chosen specifically to help preserve fertility. By keeping the testes stimulated rather than idle, they support ongoing sperm production — including for men on testosterone therapy and men who want to conceive now or later. Discuss your fertility goals with your provider, who monitors your response with bloodwork.
HCG vs gonadorelin — what's the difference?
HCG mimics LH and acts directly on the testes. Gonadorelin is a GnRH analog that works one step higher — it prompts the pituitary to release LH and FSH, which then signal the testes. Both keep the testes active; the right choice depends on your labs, goals, and your provider's clinical judgment. Both may be prescribed as compounded preparations.
Do I need bloodwork first, and how is it monitored?
Yes. Hormone therapy is guided by real lab testing, not a questionnaire. Bloodwork gives your provider a baseline — including testosterone, LH, FSH, and estradiol — and guides your starting protocol; follow-up labs then track how you respond. Your provider monitors for possible side effects such as injection-site reactions, water retention, changes in estradiol, mood changes, and gynecomastia risk if estradiol rises. These are prescription medications that require ongoing provider oversight and may be prescribed as compounded preparations.
How is it prescribed and shipped?
After your online visit and bloodwork, a licensed provider reviews your information. If HCG or gonadorelin is appropriate, your prescription ships discreetly to your door in unmarked packaging, with refills to keep you on schedule. Prescription approval is not guaranteed and is subject to provider review.
