A compounded night cream for fine lines, firmness and dull skin — estriol 0.3% and tretinoin with alpha-lipoic acid, vitamin C and hyaluronic acid — prescribed online, reviewed by licensed providers, prepared by a U.S. 503A pharmacy and shipped discreetly to all 50 states.
$477 for 3 months
Choose your formula
Supply
One payment for a 3-month supply.
A few private questions, then a licensed provider reviews your answers.
The formula
A compounded prescription night cream
This is an anti-aging night cream that pairs a low dose of estriol, a mild estrogen, with tretinoin and antioxidants. Ours is compounded by a U.S. 503A pharmacy; compounded formulas are not themselves FDA-approved.
Estriol applied to the skin is studied for skin thickness and elasticity, tretinoin speeds cell turnover and collagen renewal, alpha-lipoic acid and vitamin C are antioxidants, and hyaluronic acid holds moisture. The tretinoin comes in three strengths so your provider can start gently.
Through ForbiddenRx, a licensed provider reviews your skin and health history, including any hormone-related history, and decides whether this cream, and which strength, is right for you.
With age, skin makes less collagen and elastin, holds less moisture and renews itself more slowly. Falling estrogen around menopause speeds this up, and sun exposure breaks collagen down further. The result is fine lines, thinner skin and a duller surface.
Collagen production slows every year. Tretinoin is the long-studied topical for rebuilding it.
Skin has estrogen receptors. Lower estrogen after menopause is linked to thinner, drier skin; topical estriol is studied for this.
Over-the-counter night creams use retinol and moisturizers at fixed, gentler strengths. This cream uses prescription tretinoin and estriol, with a provider choosing the strength.
| Retinol night cream (OTC) | Tretinoin alone (Rx) | Anti-Aging Night Cream (Rx) | |
|---|---|---|---|
| Retinoid | Retinol (weaker) | Tretinoin | Tretinoin, three strengths |
| Estriol | No | No | Yes, 0.3% |
| Antioxidants | Sometimes | No | Alpha-lipoic acid + vitamin C |
| Provider involved | No | Yes | Yes — reviews your skin & history |
Results build slowly and depend on daily sun protection. Your provider decides whether an estriol cream suits your health history.
Three things working together on aging skin.
Tretinoin speeds cell turnover and supports new collagen over months of use.
Estriol 0.3%, a mild estrogen, is studied for skin thickness, moisture and elasticity.
Alpha-lipoic acid and vitamin C are antioxidants; hyaluronic acid holds water in the skin.
It's for adults with fine lines, thinning or dull skin, most often women around or after menopause. A provider confirms it's appropriate for your skin and health history.
Lines around the eyes, mouth and forehead.
Skin that has lost firmness or bounce.
Skin changes that came with falling estrogen.
Retinol and over-the-counter creams haven't done enough.
Avoid it if you're pregnant, trying to conceive or breastfeeding, because it contains tretinoin. Because it contains estriol, tell your provider about any breast, uterine or ovarian cancer, unexplained vaginal bleeding, or a history of blood clots or stroke. Tell them too about eczema, broken skin, or a past reaction to retinoids.
You complete a private online visit, a licensed provider reviews it, and — if appropriate — your prescription ships to your door. No insurance required, no in-person appointment, no waiting room.
A few private questions about your skin, goals, and history, on your own time.
A provider licensed in your state reviews your information and, if appropriate, writes your prescription.
Shipped from a U.S. pharmacy in plain, unmarked packaging to all 50 states. Reorder anytime from your dashboard, and our support team is an email or call away.
Your price is shown before you pay. No insurance needed.
This is a compounded topical. Which strength you use, how much and how often are set by the provider who reviews your visit. We deliberately do not publish a regimen here, because that is a clinical decision about you, not a product specification.
It contains tretinoin and estriol. Do not use it if you are pregnant, planning to become pregnant, or breastfeeding. Tell your provider about any hormone-sensitive cancer, unexplained bleeding, blood clots, all medications and any skin conditions before starting.
Possible side effects include:
Stop and contact your provider if you develop severe irritation, a rash, unexpected bleeding, or leg pain or swelling.
A side-by-side look at the prescription skin options available through ForbiddenRx. Your provider helps you choose what's right.
| Treatment | What it is | Best for | Form | For | Rx required |
|---|---|---|---|---|---|
| Tretinoin | A prescription retinoid (vitamin A) | Acne + anti-aging | Cream / gel | Adults | Yes |
| Melasma Cream | Tretinoin / hydrocortisone / hydroquinone 4% or 8% | Melasma & dark patches | Cream | Adults | Yes |
| Luminous Gel | Kojic / tranexamic acid / tretinoin | Melasma, hydroquinone-free | Gel | Adults | Yes |
| Clarity Cream | Clindamycin / spironolactone / tretinoin | Acne | Cream | Adults | Yes |
| Rosacea Cream | Azelaic acid / ivermectin / metronidazole | Rosacea | Cream | Adults | Yes |
| Anti-Aging Night Cream This page | Estriol / tretinoin / vitamin C | Fine lines & firmness | Night cream | Adults | Yes |
| Under-Eye Cream | Caffeine / tretinoin / glycolic acid | Dark circles & puffiness | Eye cream | Adults | Yes |
| Scar Gel | Silicone / betamethasone / lidocaine | Raised scars | Gel cream | Adults | Yes |
| GHK-Cu Cream | A copper-peptide repair cream | Firmness & recovery | Cream | Adults | Yes |
It combines tretinoin, which renews skin and supports collagen, estriol, a mild estrogen studied for skin thickness and elasticity, and the antioxidants alpha-lipoic acid and vitamin C, with hyaluronic acid for moisture.
Skin responds to estrogen, and lower estrogen after menopause is linked to thinner, drier skin. Estriol is a mild estrogen used here in a small amount on the skin. Your provider decides whether it suits your health history.
They differ only in tretinoin: Lite 0.025%, Regular 0.05% and High 0.1%. Most people start lower and move up if their skin tolerates it. Your provider chooses.
Skin texture can improve within weeks; fine lines and firmness change over several months of consistent use with daily sun protection. Results vary.
No. It contains tretinoin and estriol, which should be avoided during pregnancy, while trying to conceive, and while breastfeeding.
Physicians, NPs & PAs licensed in your state
U.S.-based compounding partners
We confirm your state during intake
Complete a private online visit and a licensed provider decides whether the night cream is right for you, and which strength.
Written by ForbiddenRx and checked against FDA prescribing information and published sources · Updated October 2026. It is general information, not a review of your own health; your provider decides what is right for you. It is provided for general educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk with a licensed provider about your individual skin and health.
This page is educational and is not medical advice.